Reaktion #68836

Reaktionsgleichung

(S)-1-(4-bromophenyl)ethylamine

acetic anhydride

→

(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen the cooling is removed
2. 2
   WaschenAfterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
3. 3
   Trocknenlayer is dried with MgSO4
4. 4
   Sonstigethe solvent is removed in vacuo
5. 5
   SonstigeThe crude product is used without further purification

Vorschrift

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried with MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.

Quelle