Reaktion #68834

Reaktionsgleichung

4-hydroxyphenylacetone

ammonia

hydrogen

→

1-(4-Hydroxyphenyl)propane-2-amine

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter complete reaction
2. 2
   Filtrationthe mixture is filtrated
3. 3
   Sonstigethe solvent is removed in vacuo
4. 4
   Sonstigethe crude product is purified by HPLC (MeOH/H2O/NH3)

Vorschrift

A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).

Quelle