Reaktion #68801

ord-50a28f7ae2de4c3ba7ddb1ea6c454f6f

Reaktionsgleichung

FC(F)(F)c1ccc(OC2CNC2)nc1
2-(Azetidin-3-yloxy)-5-trifluoromethyl-pyridine
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide
→
CC(=O)N[C@@H](C)c1ccc(N2CC(Oc3ccc(C(F)(F)F)cn3)C2)cc1
(S)—N-(1-{4-[3-(5-Trifluoromethyl-pyridin-2-yloxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Edukte

FC(F)(F)c1ccc(OC2CNC2)nc1
2-(Azetidin-3-yloxy)-5-trifluoromethyl-pyridine
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
50°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeExample 8.8 is prepared analogously to 8.1
  2. 2
    SonstigeReaction conditions

Vorschrift

Example 8.8 is prepared analogously to 8.1. 2-(Azetidin-3-yloxy)-5-trifluoromethyl-pyridine and (S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide (I.1) are used as starting materials. Reaction conditions are stirring for 12 h at 50° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08530461B2uspto-grants-2013_09