Reaktion #68800

ord-86d8cf40d1374895b9825a91273532d1

Reaktionsgleichung

c1ccc(COc2ccnc(OC3CNC3)c2)cc1
2-(Azetidin-3-yloxy)-4-benzyloxy-pyridine
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide
→
CC(=O)N[C@@H](C)c1ccc(N2CC(Oc3cc(OCc4ccccc4)ccn3)C2)cc1
(S)—N-(1-{4-[3-(4-Benzyloxy-pyridin-2-yloxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Edukte

c1ccc(COc2ccnc(OC3CNC3)c2)cc1
2-(Azetidin-3-yloxy)-4-benzyloxy-pyridine
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeExample 8.7 is prepared analogously to 8.1

Vorschrift

Example 8.7 is prepared analogously to 8.1. 2-(Azetidin-3-yloxy)-4-benzyloxy-pyridine (IX.3) and (S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide (I.1) are used as starting materials.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08530461B2uspto-grants-2013_09