Reaktion #68798

ord-28757e03b49a4eccbe90e35c5a61a548

Reaktionsgleichung

c1ccc(COc2ccc(OC3CNC3)cc2)cc1
3-(4-Benzyloxy-phenoxy)-azetidine
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide
→
CC(=O)N[C@@H](C)c1ccc(N2CC(Oc3ccc(OCc4ccccc4)cc3)C2)cc1
(S)—N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

Edukte

c1ccc(COc2ccc(OC3CNC3)cc2)cc1
3-(4-Benzyloxy-phenoxy)-azetidine
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
30°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeExample 8.5 is prepared analogously to 8.1
  2. 2
    SonstigeReaction conditions

Vorschrift

Example 8.5 is prepared analogously to 8.1. 3-(4-Benzyloxy-phenoxy)-azetidine and (S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide (I.1) are used as starting materials. Reaction conditions are stirring for 2 days at 30° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08530461B2uspto-grants-2013_09