Reaktion #68789

Reaktionsgleichung

Water

(2,2-difluorocyclopropyl)methanol

sodium hydride

2-bromo-6-fluoropyridine

→

desired product

2-Bromo-6-(2,2-difluoro-cyclopropylmethoxy)-pyridine

Lösungsmittel

DMF

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe mixture is filtered
2. 2
   Einengenconcentrated in vacuo
3. 3
   SonstigeThe residue is purified by HPLC (C18 RP Sunfire, acetonitrile/water (+0.1% TFA))

Vorschrift

To 307 mg (2.84 mmol) (2,2-difluorocyclopropyl)methanol in 1,4-dioxane (10 mL) is added 69 mg (2.84 mmol) sodium hydride and 500 mg (2.84 mmol) 2-bromo-6-fluoropyridine. The mixture is stirred for 2 h at 90° C. Water and DMF are added and the mixture is filtered and concentrated in vacuo. The residue is purified by HPLC (C18 RP Sunfire, acetonitrile/water (+0.1% TFA)) to yield the desired product.

Quelle