Reaktion #68774

Reaktionsgleichung

acetic anhydride

(S)-1-(4-bromophenyl)-ethylamine

NaHCO3

→

(S)—N-[1-(4-Bromo-phenyl)-ethyl]-acetamide

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction temperature below 30° C
2. 2
   SonstigeThe organic layer is separated
3. 3
   Waschenwashed with water
4. 4
   Trocknendried over magnesium sulphate
5. 5
   Sonstigethe solvent is removed by evaporation

Vorschrift

23.6 mL (250 mmol) acetic anhydride are added to 50.0 g (250 mmol) (S)-1-(4-bromophenyl)-ethylamine in 200 mL DCM while keeping the reaction temperature below 30° C. Stirring is continued for 12 h at rt. After that time, saturated NaHCO3-solution is added. The organic layer is separated, washed with water, dried over magnesium sulphate and the solvent is removed by evaporation.

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