Reaktion #68760

Reaktionsgleichung

1-acetyl-3,3-dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one

sodium hydroxide

→

3,3-Dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe reaction solution was extracted with 80 ml of methyl tert-butyl ether
2. 2
   WaschenThe organic phase was washed with 30 ml of water and with 30 ml of saturated NaCl solution
3. 3
   Trocknendried over MgSO4
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

464 mg of 1-acetyl-3,3-dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one were dissolved in 4 ml of ethanol, and 1 ml of 1N sodium hydroxide solution was added. The reaction mixture was then stirred at room temperature for one hour. The reaction solution was extracted with 80 ml of methyl tert-butyl ether. The organic phase was washed with 30 ml of water and with 30 ml of saturated NaCl solution, dried over MgSO4 and concentrated under reduced pressure. This gave 354 mg of 3,3-dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one as a colorless solid.

Quelle