Reaktion #687057

Reaktionsgleichung

4-oxo-piperidine-1-carboxylic acid tert-butyl ester

2-chlorobenzylamine

(2-nitro-vinyl)-benzene

→

title compound

1-(2-Chloro-benzyl)-3-phenyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

Reaktionsbedingungen

Vorschrift

The title compound (113.8 mg) was prepared from 0.55 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 334 μL of 2-chlorobenzylamine, 0.40 g of (2-nitro-vinyl)-benzene, and without SiO2. MS (ESI): exact mass calculated for C20H19ClN2, 322.12. found, m/z 323.2 [M+H]+. 1H NMR (500 MHz, CD3OD): 7.46 (m, 1H), 7.37-7.26 (m, 6H), 7.22-7.19 (m, 1H), 7.07 (s, 1H), 6.85-6.82 (m, 1H), 5.25 (s, 2H), 4.39 (s, 2H), 3.54 (t, J=6.3 Hz, 2H), 2.88 (t, J=6.3 Hz, 2H).

Quelle