Reaktion #686146

Reaktionsgleichung

4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline

2-fluoro-6-methoxyphenol

2,4-difluoro-1-nitrobenzene

4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline

2-aminothiazole

→

N-[4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea

Ausbeute 65.0%

4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene

Ausbeute 65.0%

Reaktionsbedingungen

Vorschrift

4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.91 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 2,4-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure F. This compound was reduced to 4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.61 g, 75%) following the general procedure C. N-[4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (122 mg, 65%) was prepared from 4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Quelle