Reaktion #686121

Reaktionsgleichung

2-(2-methylsulfanylphenoxy)aniline

2-hydroxythioanisole

1-fluoro-2-nitrobenzene

2-(2-methylsulfanylphenoxy)aniline

2-aminothiazole

→

N-[2-(2-Methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea

Ausbeute 65.0%

2-(2-Methylsulfanylphenoxy)-1-nitrobenzene

Ausbeute 68.0%

Reaktionsbedingungen

Vorschrift

2-(2-Methylsulfanylphenoxy)-1-nitrobenzene (0.88 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-methylsulfanylphenoxy)aniline (0.53 g, 68%) following general procedure B. N-[2-(2-Methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (115 mg, 65%) was prepared from 2-(2-methylsulfanylphenoxy)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Quelle