Reaktion #685891

ord-aea0dfabc5674cbd80f3971836f8dec7

Reaktionsgleichung

Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc1
compound 13
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc1
N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide
COC(=O)C(=O)c1ccc(OCCN2CCOCC2)c2ccccc12
compound 12
COC(=O)C(=O)c1ccc(OCCN2CCOCC2)c2ccccc12
[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-oxo-acetic acid methyl ester
COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O
compound 14
COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O
N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide
→
COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O
title compound
COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(C(C)(C)C)cc1NS(C)(=O)=O
N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide

Edukte

Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc1
compound 13
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc1
N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide
COC(=O)C(=O)c1ccc(OCCN2CCOCC2)c2ccccc12
compound 12
COC(=O)C(=O)c1ccc(OCCN2CCOCC2)c2ccccc12
[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-oxo-acetic acid methyl ester
COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O
compound 14
COc1c(N)cc(C(C)(C)C)cc1NS(C)(=O)=O
N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by the same method described for compound 13 starting from compound 12 and compound 14. Calculated mass=583. Observed mass=584.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07897599B2uspto-grants-2011_03