Reaktion #68536

Reaktionsgleichung

5-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

diphenyl ether

→

Methoxy-1H-[1,5]naphthyridin-4-one

Lösungsmittel

hexane

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA two-necked round bottomed flask equipped with an air condenser
2. 2
   Temperaturwas cooled to RT
3. 3
   Filtrationfiltered
4. 4
   Sonstigeto obtain a dark solid
5. 5
   Filtrationfiltered
6. 6
   Sonstigeto obtain product as a brown solid

Vorschrift

A two-necked round bottomed flask equipped with an air condenser was charged with 5-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (18 g) and diphenyl ether (180 mL). The reaction mixture was heated at 240-250° C. for 5 min under N2 atmosphere after which it was cooled to RT, diluted with hexane and filtered to obtain a dark solid. The crude product was refluxed in hexane for 30 min and filtered to obtain product as a brown solid.

Quelle