Reaktion #68534

Reaktionsgleichung

ammonia

3-Bromo-5-methoxypyridine

NaOH

→

3-amino-5-methoxypyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to RT
2. 2
   Extraktionextracted with CH2Cl2
3. 3
   SonstigeAfter evaporation of volatiles

Vorschrift

3-Bromo-5-methoxypyridine (15 g) was added to a pressure vessel, and CuSO4 (3.9 g) and 25% aq ammonia (150 mL) were added. The reaction mixture was stirred for 4 h at 135° C., then cooled to RT, basified with aqueous NaOH solution, and extracted with CH2Cl2. After evaporation of volatiles, 3-amino-5-methoxypyridine was obtained as yellow solid.

Quelle