Reaktion #68531

Reaktionsgleichung

5-[(3-Bromo-2-methoxy-pyridin-4-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

diphenyl ether

→

8-Bromo-7-methoxy-1H-[1,6]naphthyridin-4-one

Lösungsmittel

hexane

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA two neck round bottomed flask equipped with an air condenser
2. 2
   Temperaturwas cooled to RT
3. 3
   Filtrationfiltered
4. 4
   Sonstigeto obtain a dark solid
5. 5
   Filtrationfiltered

Vorschrift

A two neck round bottomed flask equipped with an air condenser was charged with 5-[(3-Bromo-2-methoxy-pyridin-4-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (23 g, 64 mmol) and diphenyl ether (230 mL). The reaction mixture was heated at 250° C. for 30 min under nitrogen atmosphere after which it was cooled to RT, diluted with hexane and filtered to obtain a dark solid. The crude product was refluxed in hexane for 30 min and filtered to obtained 8-Bromo-7-methoxy-1H-[1,6]naphthyridin-4-one as a brown solid.

Quelle