Reaktion #684992

Reaktionsgleichung

1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol

maleic acid

→

achromatic crystal

Ausbeute 88.4%

1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol maleate

Ausbeute 88.4%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was gradually cooled
2. 2
   SonstigeThereafter, precipitated crystals
3. 3
   Filtrationwere collected by filtration

Vorschrift

8.00 g of 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol was dissolved in 56 ml of acetone. Thereafter, 3.19 g of maleic acid was added thereto, and the obtained mixture was heated to 60° C. for dissolution. The reaction mixture was gradually cooled, and it was then stirred at 5° C. for 30 minutes. Thereafter, precipitated crystals were collected by filtration, so as to obtain 9.89 g of an achromatic crystal, 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-3-azetidinol maleate.

Quelle