Reaktion #684975

Reaktionsgleichung

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

Ausbeute 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

Ausbeute 84.4%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe reaction mixture was washed with saturated brine
2. 2
   Einengenconcentrated under reduced pressure
3. 3
   SonstigeThe residue was purified by silica gel column chromatography

Vorschrift

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

Quelle