Reaktion #684971

Reaktionsgleichung

Trifluoroacetic acid

compound

2-(4-Butylbenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

ethyl acetate

→

title compound

Ausbeute 88.8%

2-(4-Butylbenzyl)-3-pyridinol

Ausbeute 88.8%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe reaction mixture was washed with saturated brine
2. 2
   Einengenconcentrated under reduced pressure
3. 3
   SonstigeThe residue was purified by silica gel column chromatography

Vorschrift

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

Quelle