Reaktion #684966

Reaktionsgleichung

compound

1-(4-Butylbenzyl)-7-(1-ethynyl)isoquinoline

→

title compound

Ausbeute 10.4%

1-(4-Butylbenzyl)-7-ethylisoquinoline

Ausbeute 10.4%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst was removed by filtration
2. 2
   Einengenthe filtrate was concentrated
3. 3
   SonstigeThe residue was purified by silica gel column chromatography

Vorschrift

Palladium-carbon (10%, 5.0 mg) was added to a solution of the compound of Example B158 (2.0 mg) in tetrahydrofuran (2.0 ml), and the mixture was stirred at room temperature under nitrogen atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (0.21 mg).

Quelle