Reaktion #684965

Reaktionsgleichung

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

Ausbeute 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

Ausbeute 94.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 19 hours
2. 2
   EinengenThe mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   Sonstigeto precipitate crystals
5. 5
   FiltrationThe obtained crystals were collected by filtration
6. 6
   Waschenwashed with water
7. 7
   Sonstigedried

Vorschrift

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

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