Reaktion #684964

Reaktionsgleichung

Phosphorus oxychloride

compound

N-[2-Hydroxy-2-(3-methoxyphenyl)ethyl]-2-(4-butylphenyl)-acetamide

sodium hydrogencarbonate

→

title compound

Ausbeute 15.8%

1-(4-Butylbenzyl)-6-methoxyisoquinoline

Ausbeute 15.8%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 1 hour 30 minutes
2. 2
   TemperaturThe mixture was cooled on ice
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   SonstigeThe residue was purified by silica gel column chromatography

Vorschrift

Phosphorus oxychloride (1.6 ml) was added to a solution of the compound of Example B145 (600 mg, 1.7 mmol) in acetonitrile (15 ml), and the mixture was stirred under reflux for 1 hour 30 minutes. The mixture was cooled on ice, made alkaline with a 5% aqueous sodium hydrogencarbonate solution, extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (82 mg).

Quelle