Reaktion #68492

Reaktionsgleichung

(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine

6-chloropurine

sec-butanol

→

N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-7H-purin-6-amine

Ausbeute 32.8%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigesealed
2. 2
   EinengenThe reaction mixture was concentrated
3. 3
   Sonstigethe yellow residue was purified by MPLC
4. 4
   Wascheneluting with a gradient of 3-8% MeOH/DCM over 80 minutes

Vorschrift

A 15 mL tube was charged with (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine (0.100 g, 0.444 mmol), 6-chloropurine (0.103 g, 0.666 mmol), and sec-butanol (3.00 ml, 32.4 mmol), sealed, then heated in a 100° C. oil bath for 5 hours. The reaction mixture was concentrated and the yellow residue was purified by MPLC using a 40 g RediSep column, eluting with a gradient of 3-8% MeOH/DCM over 80 minutes. N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-7H-purin-6-amine (0.0500 g, 32.8% yield) was isolated as the hydrochloride salt.

Quelle