Reaktion #68488

Reaktionsgleichung

triethylamine

tributyl(ethynyl)stannane

nitroethane

phenyl isocyanate

→

product

3-methyl-5-(tributylstannyl)isoxazole

Lösungsmittel

water

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITThe mixture was left
2. 2
   workup.STIRRINGto stir at 50° C. overnight
3. 3
   Filtrationfiltered though a celite plug
4. 4
   Extraktionthe resulting filtrate was extracted with toluene
5. 5
   TrocknenOrganic extracts were dried over magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   Einengenthen concentrated

Vorschrift

To a solution of nitroethane (0.0952 ml, 1.33 mmol) in benzene (2 mL) was added phenyl isocyanate (0.291 ml, 2.66 mmol). The solution was stirred at 50° C. for ten minutes followed by the addition of triethylamine (0.00925 ml, 0.0666 mmol) and tributyl(ethynyl)stannane (0.365 ml, 1.27 mmol). The mixture was left to stir at 50° C. overnight. The solution was diluted with water and filtered though a celite plug, the resulting filtrate was extracted with toluene. Organic extracts were dried over magnesium sulfate and filtered then concentrated to yield the product as a yellow oil.

Quelle