Reaktion #684661

Reaktionsgleichung

N-isopropylaniline

phosgene

→

Phenyl Isopropyl Carbamoyl Chloride

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige2 hours
2. 2
   TemperaturThe mixture was refluxed for 1 hour
3. 3
   Sonstigeto remove excess phosgene
4. 4
   Temperaturcooled
5. 5
   Filtrationthe amine hydrochloride was filtered off
6. 6
   SonstigeThe solvent was evaporated
7. 7
   Sonstigethe residue recrystallised from benzene-petroleum ether 1:1
8. 8
   Sonstigegiving 21.6 g, m.p. 89°-90° C.

Vorschrift

A solution of N-isopropylaniline (30 g) in dry benzene (150 ml) was cooled to 5°-10° C and phosgene passed therethrough slowly for 11/2 hours. The mixture was refluxed for 1 hour to remove excess phosgene, cooled and the amine hydrochloride was filtered off. The solvent was evaporated and the residue recrystallised from benzene-petroleum ether 1:1, giving 21.6 g, m.p. 89°-90° C.

Quelle