Reaktion #6845

Reaktionsgleichung

5-benzyloxy-1H-indole

2-nitro-propene

→

5-benzyloxy-3-(2-nitro-propyl)-1H-indole

Lösungsmittel

benzene

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was heated
2. 2
   Temperaturat reflux under a nitrogen atmosphere overnight
3. 3
   SonstigeThe volatiles were removed
4. 4
   Sonstigeresidue was purified by silica gel chromatography (20% EtOAc/hexanes)

Vorschrift

To a stirred 0.5 M benzene solution of 5-benzyloxy-1H-indole (6 mL) was added 2-nitro-propene (5.2 mL of the 10% benzene solution). The reaction was heated at reflux under a nitrogen atmosphere overnight. The volatiles were removed and residue was purified by silica gel chromatography (20% EtOAc/hexanes) to afford 5-benzyloxy-3-(2-nitro-propyl)-1H-indole (550 mg).

Quelle