Reaktion #684201

Reaktionsgleichung

Chloroform

2-cyclopentyl-2-methyl-6,7-dichloro-1,5-indandiol

2-cyclopentyl-2-methyl-6,7-dichloroindan-1,5-diol

sodium hydroxide

→

α,α-dimethyl-(1-oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid

Lösungsmittel

acetone

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is refluxed for 5 hours
2. 2
   Sonstigeevaporated to dryness at reduced pressure
3. 3
   workup.DISSOLUTIONThe residue is dissolved in water
4. 4
   Filtrationfiltered

Vorschrift

To a refluxing solution of 2-cyclopentyl-2-methyl-6,7-dichloro-1,5-indandiol (Example 5, Step C), (15.6 g., 0.05 mole) in acetone (500 ml.) in an inert atmosphere is added solid sodium hydroxide (12.6 g., 0.25 mole). Chloroform (7.6 g., 0.69 mole) in acetone (50 ml.) is added dropwise during a ten-minute period. The reaction mixture is refluxed for 5 hours, then evaporated to dryness at reduced pressure. The residue is dissolved in water, filtered and acidified with hydrochloric acid affording α,α-dimethyl-(1-oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid.

Quelle