Reaktion #6836

Reaktionsgleichung

Acetic acid

3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride

Acetaldehyde

→

2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe tube was cooled to rt
2. 2
   SonstigeThe solvent was evaporated

Vorschrift

Acetic acid was added dropwise to a solution of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (200 mg) in 7 mL of methanol until the pH=4. Acetaldehyde (0.2 mL) was added and the mixture was heated at 75° C. in a sealed tube for 1 h. The tube was cooled to rt and unsealed. The solvent was evaporated yielding 160 mg of 2,3,4,9-tetrahydro-1H-β-carbolin-6-ol.

Quelle