Reaktion #683587

ord-01554f2260874283870fcc1abb25fd1c

Reaktionsgleichung

CN(C)Cc1nnc(CO)n1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl
2'-chloro-5-nitro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone
CS(=O)(=O)Cl
methanesulfonyl chloride
C#CCN
propargylamine
→
C#CCNCc1nnc(CN(C)C)n1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl
2'-chloro-5-nitro-2-[3-[[(2-propynyl)amino]methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone

Edukte

CN(C)Cc1nnc(CO)n1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl
2'-chloro-5-nitro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone
CS(=O)(=O)Cl
methanesulfonyl chloride
C#CCN
propargylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In the manner given in Example 47, 2'-chloro-5-nitro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with methanesulfonyl chloride followed by propargylamine, to give 2'-chloro-5-nitro-2-[3-[[(2-propynyl)amino]methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04010177uspto-grants-1977_03