Reaktion #683473

Reaktionsgleichung

potassium carbonate

3',4'-dihydrospiro[ cyclohexane-1,2'(1'H)-naphthalen]-4-ylamine hydrochloride

3',4'-Dihydrospiro[cyclohexane- 1,2'(1'H)-naphthalen]-4-ylamine hydrochloride

ethanol

1,5-diiodopentane

→

1-[3',4'-dihydrospiro[cyclohexane-1,2'(1'H)-naphthalen]-4-yl]piperidine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux temperature for about 18 hours
2. 2
   TemperaturThe mixture after cooling
3. 3
   Sonstigethe solid collected on
4. 4
   Filtrationa filter
5. 5
   Sonstigerecrystallized from methanol

Vorschrift

The amine prepared from 1.5 g. of 3',4'-dihydrospiro[ cyclohexane-1,2'(1'H)-naphthalen]-4-ylamine hydrochloride [I(c)] (prepared as in Example 10C), 1.9 g. of 1,5-diiodopentane and 1.6 g. of potassium carbonate in 18 ml. of ethanol is stirred at reflux temperature for about 18 hours. The mixture after cooling is diluted with water, the solid collected on a filter and recrystallized from methanol to give 1-[3',4'-dihydrospiro[cyclohexane-1,2'(1'H)-naphthalen]-4-yl]piperidine [I(c)].

Quelle