Reaktion #68309

Reaktionsgleichung

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

Compound 3

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

HCl Et2O

→

crude title compound

1-Benzyl-2-isopropyl-6-methoxy-1H-indole

Lösungsmittel

EtOAc

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationwas filtered
2. 2
   workup.ADDITIONTo the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml)
3. 3
   FiltrationThis was then filtered
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a solution of 2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol (Compound 3, 1.05 g, 3.57 mmol) in EtOAc (35 ml) and EtOH (15 ml) was added 10% Pd—C (190 mg, 0.18 mmol) and HCl-Et2O (1.0 M, 1.25 ml, 1.25 mmol). The mixture was stirred under hydrogen gas (atmospheric pressure) for 1 h and was filtered. To the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml), followed by Na2SO4 and MgSO4. This was then filtered and concentrated in vacuo to yield the crude title compound as a yellow solid.

Quelle