Reaktion #682713

ord-78fa33bf4e744c9492bba467fa00a200

Reaktionsgleichung

N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O
H-Lys(Z)—OH
N[C@@H](CCC(=O)OCc1ccccc1)C(=O)O
H-Glu(OBn)-OH
→
O=C(NCCCCC1NC(=O)OC1=O)OCc1ccccc1
Lys-NCA
N[C@@H](CCC(=O)O)C(=O)O
Glu

Edukte

N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O
H-Lys(Z)—OH
N[C@@H](CCC(=O)OCc1ccccc1)C(=O)O
H-Glu(OBn)-OH

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

H-Lys(Z)—OH and H-Glu(OBn)-OH were purchased from Chem-Impex International (Des Plaines, Ill.) and used as received. Glu-NCA and Lys-NCA were prepared by following previously reported procedures (Lu, H.; Cheng, J. J. Am. Chem. Soc. 2007, 129, 14114-14115).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09243040B2uspto-grants-2016_01