Reaktion #68238

Reaktionsgleichung

1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one

hydrogen chloride ethyl acetate

→

1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one hydrochloride

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   SonstigeThe solvent was removed under reduced pressure, ethyl acetate
3. 3
   workup.ADDITIONwas added
4. 4
   Filtrationthe resulting solid was filtered

Vorschrift

To 10 mL of a chloroform solution containing 228 mg of 1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 247 mg of 1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one hydrochloride as a pale brown solid.

Quelle