Reaktion #68090

Reaktionsgleichung

tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate

hydrogen chloride ethyl acetate

→

quinolin-2(1H)one hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITleft
2. 2
   SonstigeThe solvent was removed under reduced pressure, 2-propanol
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   Sonstigeobtained
5. 5
   Sonstigethe solvent was removed under reduced pressure
6. 6
   workup.ADDITIONEthyl acetate was added to the residue
7. 7
   Sonstigethus obtained
8. 8
   Filtrationthe resulting solid was filtered

Vorschrift

To 0.13 g of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 10 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added, and left to stand at room temperature for 3 days. The solvent was removed under reduced pressure, 2-propanol was added to the residue obtained and the solvent was removed under reduced pressure. Ethyl acetate was added to the residue thus obtained and the resulting solid was filtered to afford 0.10 g of 1-(2-(4-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-quinolin-2(1H)one hydrochloride as a yellow solid.

Quelle