Reaktion #680524

Reaktionsgleichung

(R)-5-(5-bromo-2-fluoro-phenyl)-5-methyl-morpholin-3-one

trimethyloxonium tetrafluoroborate

ammonium chloride

→

title compound

(R)-5-(5-Bromo-2-fluoro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn analogy to step a) in the synthesis of building block D

Vorschrift

In analogy to step a) in the synthesis of building block D, the treatment of (R)-5-(5-bromo-2-fluoro-phenyl)-5-methyl-morpholin-3-one with trimethyloxonium tetrafluoroborate followed by the nucleophilic substitution with ammonium chloride yielded the title compound; its hydrochloride was obtained as a white solid (74%). Mass (calculated) C11H12BrFN2O [287.13]; (found) [M+H]+=287, [M+2+H]+=289.

Quelle