Reaktion #679682

Reaktionsgleichung

m-toluidine

tri(tert-butyl)phosphine

9-(3-bromophenyl)-9-phenylfluorene

sodium tert-butoxide

→

white solid

Ausbeute 82.0%

3-Methylphenyl-3-(9-phenyl-9H-fluoren-9-yl)phenylamine

Ausbeute 82.0%

Lösungsmittel

hexane

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas set to 60° C.
2. 2
   FiltrationAfter the stirring, the mixture was suction-filtered through Florisil (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135), Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855), and alumina
3. 3
   Sonstigeto give a filtrate
4. 4
   EinengenThe filtrate was concentrated
5. 5
   Sonstigeto give a solid, which
6. 6
   Sonstigewas then purified by silica gel column chromatography (
7. 7
   SonstigeRecrystallization from a mixed solvent of toluene and hexane

Vorschrift

There were placed 3.2 g (8.1 mmol) of 9-(3-bromophenyl)-9-phenylfluorene and 2.3 g (24.1 mmol) of sodium tert-butoxide in a 200 mL three-neck flask. The air in the flask was replaced with nitrogen. Then, 40.0 mL of toluene, 0.9 mL (8.3 mmol) of m-toluidine, and 0.2 mL of a 10% hexane solution of tri(tert-butyl)phosphine were added to this mixture. The temperature of this mixture was set to 60° C., and 44.5 mg (0.1 mmol) of bis(dibenzylideneacetone)palladium(0) was added to the mixture. The temperature of the mixture was raised to 80° C., and the mixture was stirred for 2.0 hours. After the stirring, the mixture was suction-filtered through Florisil (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135), Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855), and alumina to give a filtrate. The filtrate was concentrated to give a solid, which was then purified by silica gel column chromatography (developing solvent: hexane/toluene in a 1:1 ratio). Recrystallization from a mixed solvent of toluene and hexane gave 2.8 g of a white solid, which was the object of the synthesis, in 82% yield. A synthesis scheme of the above Step 1 is illustrated below.

Quelle