Reaktion #67872

ord-a8d77d18ff7d43ffb38c90f05ae20aaa

Reaktionsgleichung

O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
O=C(O)c1ccncc1Nc1ccc(I)cc1F
intermediate 1
O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
NCc1ccc(F)cc1
4-fluoro-benzylamine
O=C(NCc1ccc(F)cc1)c1ccncc1Nc1ccc(I)cc1F
N-(4-Fluoro-benzyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeLC/MS [6.99 min; 466 (M+1)]

Vorschrift

N-(4-Fluoro-benzyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.25 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.33 mmol of 4-fluoro-benzylamine. LC/MS [6.99 min; 466 (M+1)]

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524911B2uspto-grants-2013_09