Reaktion #678562

Reaktionsgleichung

n-butyllithium

chlorodicyclopentylphosphine

2-bromoanisole

→

dicyclopentyl(2-methoxyphenyl)phosphine

Ausbeute 88.5%

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeUnder a nitrogen atmosphere, into a reaction vessel equipped with a dropping funnel
2. 2
   Sonstigea solution obtained
3. 3
   workup.ADDITIONwas dropped at −78° C
4. 4
   SonstigeThe resultant reaction mixture
5. 5
   Einengenwas concentrated
6. 6
   Sonstigepurified by silica gel column chromatography

Vorschrift

Under a nitrogen atmosphere, into a reaction vessel equipped with a dropping funnel were added 0.91 g of 2-bromoanisole and 20 mL of tetrahydrofuran. The resultant solution was cooled down to −78° C., then, 3.4 ml of n-butyllithium (1.62 M/hexane solution) was dropped. The resultant mixture was stirred at the same temperature for 2 hours, then, a solution obtained by dissolving 1.00 g of chlorodicyclopentylphosphine in 13 ml of tetrahydrofuran was dropped at −78° C. The resultant mixture was stirred at room temperature for 3 hours. The resultant reaction mixture was concentrated, and purified by silica gel column chromatography, to obtain 1.19 g of dicyclopentyl(2-methoxyphenyl)phosphine in the form of viscous liquid.

Quelle