Reaktion #67846

ord-07243f61c94047f395048d2eb7c30b24

Reaktionsgleichung

O=C(O)c1cc(Br)ncc1Nc1ccc(I)cc1F
2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
NCCCO
3-Amino-propan-1-ol
O=C(NCCCO)c1cc(Br)ncc1Nc1ccc(I)cc1F
2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-hydroxy-propyl)-isonicotinamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstige[9.15 min, 494, 496]

Vorschrift

2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-hydroxy-propyl)-isonicotinamide was synthesized according to General method 3, starting with 145 mg (0.33 mmol) of 2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid and 62 mg (0.82 mmol) of 3-Amino-propan-1-ol. LC/MS: [9.15 min, 494, 496]

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524911B2uspto-grants-2013_09