Reaktion #67828

ord-6ce4660d92144a9c858bce706b3ccc36

Reaktionsgleichung

O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
O=C(O)c1ccncc1Nc1ccc(I)cc1F
intermediate 1
O=C(O)c1ccncc1Nc1ccc(I)cc1F
3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid
CC(C)(C)OC(=O)NN
hydrazinecarboxylic acid tert-butylester
CC(C)(C)OC(=O)NNC(=O)c1ccncc1Nc1ccc(I)cc1F
tert-butyl 2-{3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}hydrazine-carboxylate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeLC/MS [9.37 min; 473 (M+1)]

Vorschrift

tert-butyl 2-{3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}hydrazine-carboxylate was synthesized according to the procedure for General Method 1, outlined above, starting with 3 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 5 mmol of hydrazinecarboxylic acid tert-butylester. LC/MS [9.37 min; 473 (M+1)]

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524911B2uspto-grants-2013_09