Reaktion #67794

Reaktionsgleichung

lithium bis(trimethylsilyl)amide

Lithium bis(trimethylsilyl)amide

5-fluoro-2-phenylisonicotinic acid

2-fluoro-4-iodoaniline

→

5-[(2-fluoro-4-iodophenyl)amino]-2-phenylisonicotinic acid

Ausbeute 56.6%

Lösungsmittel

EtOAc

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred for 1 h
2. 2
   TemperaturThe mixture was warmed to room temperature
3. 3
   workup.STIRRINGstirred overnight
4. 4
   Waschenwashed with dilute HCl (20 ml), water (20 ml)
5. 5
   Sonstigedried
6. 6
   Einengenconcentrated
7. 7
   SonstigePurified on Flashmaster

Vorschrift

Lithium bis(trimethylsilyl)amide (2.8 ml, 1.0 M in THF, 2.76 mmol) was added to a suspension of 5-fluoro-2-phenylisonicotinic acid (500 mg, 2.30 mmol) in THF (10 ml) at −78° C. The dark colored suspension was stirred for 30 min. In another flask, 2-fluoro-4-iodoaniline (709.30 mg, 2.99 mmol, 1.30 eq) was dissolved in (15 ml) THF and cooled to −78° C. To this solution lithium bis(trimethylsilyl)amide (5 ml, 1.00 M, 5.06 mmol, 2.20 eq) was added and the mixture was stirred for 1 h. The reaction mixture became very viscous. To this, the homogeneous solution of acid-LiHMDS mixture was added via syringe. The mixture was warmed to room temperature and stirred overnight. Diluted with EtOAc (300 ml), washed with dilute HCl (20 ml), water (20 ml), and then dried and concentrated. Purified on Flashmaster using 100 g cartridge to obtain 565 mg of 5-[(2-fluoro-4-iodophenyl)amino]-2-phenylisonicotinic acid. LC/MS: [8.59 min; 435 (M+1)]

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