Reaktion #67791

Reaktionsgleichung

5-fluoro-2-methylisonicotinic acid

2-fluoro-4-iodoaniline

lithium bis(trimethylsilyl)amide

→

5-[(2-fluoro-4-iodophenyl)amino]-2-methylisonicotinic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeYield: 30 mg, 6%, LC/MS [5.5 min; 473 (M+1)]

Vorschrift

5-[(2-fluoro-4-iodophenyl)amino]-2-methylisonicotinic acid was synthesized according to the general procedure of Method 1 as, outlined above, starting with 200 mg (1.29 mmol) of 5-fluoro-2-methylisonicotinic acid, 370 mg (1.55 mmol) of 2-fluoro-4-iodoaniline and two portions of lithium bis(trimethylsilyl)amide (3.35 ml, 3.35 mmol), and (1.55 ml, 1.55 mmol). Yield: 30 mg, 6%, LC/MS [5.5 min; 473 (M+1)]

Quelle