Reaktion #67788

Reaktionsgleichung

Water

Ammonium acetate

2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid

1,1′-carbonylbis(1H-imidazole)

→

2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

Ausbeute 59.1%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto obtain a homogeneous solution
2. 2
   workup.STIRRINGstirred for 2 h
3. 3
   Filtrationthe precipitated solid was filtered
4. 4
   Waschenwashed with hot methanol

Vorschrift

To a solution of 2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (145.0 mg, 0.33 mmol) in N,N-dimethylformamide (1.50 ml), 1,1′-carbonylbis(1H-imidazole) (60 mg, 0.36 mmol) was added, and the mixture was stirred at room temperature for 7 hours to obtain a homogeneous solution. Ammonium acetate (65 mg, 0.83 mmol) was added, and stirred for 2 h. Water (10 ml) was added, and the precipitated solid was filtered, washed with hot methanol to obtain 2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-isonicotinamide as an yellow solid (85 mg, 58%) LC/MS: [9.59 min; 436, 438]

Quelle