Reaktion #67744

ord-04fe4e8b0e4545618f2cebc94b3996f6

Reaktionsgleichung

O=C(Nc1ccc(Cc2ccccc2)cn1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(5-benzylpyridin-2-yl)cyclopropanecarboxamide
O=C(Nc1ccc(Br)cn1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(5-bromopyridin-2-yl)cyclopropanecarboxamide
Clc1cccc(Cl)c1[CH2][Zn+].[Cl-]
(2,6-dichlorobenzyl)zinc(II) chloride
→
O=C(Nc1ccc(Cc2c(Cl)cccc2Cl)cn1)C1(c2ccc3c(c2)OCO3)CC1
1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-(2,6-dichlorobenzyl)pyridin-2-yl)cyclopropanecarboxamide

Edukte

O=C(Nc1ccc(Cc2ccccc2)cn1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(5-benzylpyridin-2-yl)cyclopropanecarboxamide
O=C(Nc1ccc(Br)cn1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(5-bromopyridin-2-yl)cyclopropanecarboxamide
Clc1cccc(Cl)c1[CH2][Zn+].[Cl-]
(2,6-dichlorobenzyl)zinc(II) chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-(2,6-dichlorobenzyl)pyridin-2-yl)cyclopropanecarboxamide was synthesized using the procedure of 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-benzylpyridin-2-yl)cyclopropanecarboxamide by reacting 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-bromopyridin-2-yl)cyclopropanecarboxamide with (2,6-dichlorobenzyl)zinc(II) chloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08524910B2uspto-grants-2013_09