Reaktion #676851

Reaktionsgleichung

NaHCO3

3,5-dimethylbenzothiophene

Intermediate 12

3,5-dimethylbenzothiophene

chlorosulfonic acid

→

title compound

Ausbeute 40.0%

3,5-Dimethyl-benzothiophene-2-sulfonyl chloride

Ausbeute 40.0%

Lösungsmittel

CHCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred vigorously for 5 min
2. 2
   SonstigeThe organic phase was immediately separated
3. 3
   Trocknendried with MgSO4
4. 4
   Einengenconcentrated

Vorschrift

To a solution of 3,5-dimethylbenzothiophene (Intermediate 12) (5.0 g, 33.8 mmol) in CHCl3 (70 mL), chlorosulfonic acid (5.6 mL, 85 mmol) was added dropwise at −5° C. The reaction mixture was stirred at 0° C. for 3 h before it was poured into a mixture of ice and NaHCO3 and stirred vigorously for 5 min. The organic phase was immediately separated, dried with MgSO4 and concentrated yielding 3.5 g (40%) of the title compound.

Quelle