Reaktion #676848

Reaktionsgleichung

3-methylbenzothiophene-2-sulfonic acid

POCl3

→

title compound

Ausbeute 115.5%

3-Methylbenzothiophene-2-sulfonyl chloride

Ausbeute 115.5%

Lösungsmittel

CH2Cl2

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas quenched with ice
2. 2
   SonstigeThe organic phase was separated
3. 3
   SonstigeEvaporation of the solvents

Vorschrift

The 3-methylbenzothiophene-2-sulfonic acid (45 mg, 0.20 mmol) was mixed with POCl3 (2 mL, 20 mmol) and CH2Cl2 (2 mL) and heated at 70° C. for 6 h. The reaction mixture was diluted with CH2Cl2 before the reaction was quenched with ice and stirred at room temperature for 1 h. The organic phase was separated. Evaporation of the solvents afforded 57 mg the title compound (91%).

Quelle