Reaktion #676846

Reaktionsgleichung

Chlorosulfonic acid

5-bromo-3-methylbenzothiophene

Intermediate 9

5-bromo-3-methylbenzothiophene

→

title compound

5-Bromo-3-methyl-benzothiophene-2-sulfonyl chloride

Lösungsmittel

CHCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred vigorously for 5 min
2. 2
   SonstigeThe organic phase was immediately separated
3. 3
   Sonstigedried
4. 4
   Einengenconcentrated

Vorschrift

Chlorosulfonic acid (2.20 ml, 0.033 mmol) was added dropwise at −5° C. to a solution of 5-bromo-3-methylbenzothiophene (Intermediate 9) (3.0 g, 13.2 mmol) in CHCl3 (30 mL). The reaction mixture was stirred at 0° C. for 3 h, and then poured into a mixture of ice/NaHCO3 and stirred vigorously for 5 min. The organic phase was immediately separated, dried and concentrated to give the title compound (1.70 g, 39%).

Quelle