Reaktion #676023

Reaktionsgleichung

KF

2,2′,5′-trichloro-5-iodo-4-methoxybiphenyl

tributyl(vinyl)stannane

→

desired product

Ausbeute 92.2%

2,2′,5′-Trichloro-4-methoxy-5-vinylbiphenyl

Ausbeute 92.2%

Lösungsmittel

H2O

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was degassed
2. 2
   workup.ADDITIONback-filled with nitrogen (several cycles)
3. 3
   Temperaturat reflux for 16 h
4. 4
   workup.STIRRINGstirred for 1 h
5. 5
   SonstigeThe mixture was partitioned between ethyl acetate and water
6. 6
   TrocknenThe organic layer was dried over anhydrous Na2SO4
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated in vacuo
9. 9
   SonstigeThe residue was purified by flash column chromatography on silica gel (1-2% ethyl acetate/petroleum ether)

Vorschrift

To a stirred solution of 2,2′,5′-trichloro-5-iodo-4-methoxybiphenyl (3.4 g, 8.3 mmol) in toluene (100 mL) at room temperature, tributyl(vinyl)stannane (3.1 g, 9.9 mmol) was added followed by Pd(PPh3)4 (2 g, 1.7 mmol). The reaction mixture was degassed and back-filled with nitrogen (several cycles) and then stirred at reflux for 16 h. The mixture was allowed to cool to room temperature, a solution of KF (1.72 g, 29.7 mmol) in H2O (10 mL) was added and then stirred for 1 h. The mixture was partitioned between ethyl acetate and water. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (1-2% ethyl acetate/petroleum ether) to afford the desired product (2.4 g, 92% yield) as a white solid

Quelle