Reaktion #675796

Reaktionsgleichung

N-[3-(3-fluorophenyl)-1H-pyrazol-5-yl]acetamide

iodic acid

iodine

→

title compound

N-[3-(3-fluorophenyl)-4-iodo-1H-pyrazol-5-yl]acetamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   EinengenThe reaction mixture was concentrated in vacuo
3. 3
   Sonstigepartitioned between CH2Cl2 and 2 M Na2S2O3 aq. solution
4. 4
   SonstigeThe layers were separated
5. 5
   Waschenthe organic washed with brine
6. 6
   Trocknendried (MgSO4)
7. 7
   Einengenconcentrated in vacuo

Vorschrift

A suspension of N-[3-(3-fluorophenyl)-1H-pyrazol-5-yl]acetamide (7.6 g, 34.7 mmol), iodic acid (1.5 g, 8.5 mmol) and iodine (4.4 g, 17.3 mmol) in ethanol (200 mL) was heated at 60° C. for 1 h and cooled to room temperature. The reaction mixture was concentrated in vacuo and partitioned between CH2Cl2 and 2 M Na2S2O3 aq. solution. The layers were separated and the organic washed with brine, dried (MgSO4), and concentrated in vacuo to provide the title compound as a solid (10.8 g).

Quelle