Reaktion #67501

Reaktionsgleichung

2-cyano-3-difluoromethoxy-benzenesulfonyl chloride

thiazolidine

→

2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture is concentrated in vacuo
2. 2
   SonstigePurification by HPLC

Vorschrift

54 mg of 2-cyano-3-difluoromethoxy-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 32 I of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by HPLC affords 35 mg of 2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile.

Quelle