Reaktion #67495

Reaktionsgleichung

Et3N

5-bromovaleric acid chloride

decahydroquinoline

AcOEt

→

4-bromo-1-(octahydroquinolin-1-yl)butan-1-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe solution is then washed with water
2. 2
   Extraktionthe water re-extracted twice with AcOEt
3. 3
   WaschenThe pooled organic phases are sequentially washed with 5% solution of NaHCO3, 1N HCl and saturated ammonium chloride solution
4. 4
   TrocknenFinally the organic phase is dried over anhydrous Na2SO4, it
5. 5
   Filtrationis filtered
6. 6
   Sonstigethe solvent is evaporated under reduced pressure
7. 7
   Sonstige1.2 g of a yellow oil, which was used without subsequent purification
8. 8
   Sonstigeare obtained

Vorschrift

1.37 mL (9.9 mmol) of Et3N and 0.5 mL (4.5 mmol) of 5-bromovaleric acid chloride are added to a solution of 1 mL (4.0 mmol) of the decahydroquinoline in AcOEt. The resulting solution is kept under stirring for 18 h at rt. The solution is then washed with water, and the water re-extracted twice with AcOEt. The pooled organic phases are sequentially washed with 5% solution of NaHCO3, 1N HCl and saturated ammonium chloride solution. Finally the organic phase is dried over anhydrous Na2SO4, it is filtered and the solvent is evaporated under reduced pressure. 1.2 g of a yellow oil, which was used without subsequent purification, are obtained.

Quelle